Preclinical Characterization of Mobocertinib Highlights the Putative Therapeutic Window of This Novel EGFR Inhibitor to EGFR Exon 20 Insertion Mutations

Introduction: EGFR exon 20 insertion mutations account for 10% of all EGFR mutations and are mostly insensitive to approved EGFR tyrosine kinase inhibitors (EGFR TKIs).Novel EGFR TKIs have been developed or repurposed for these mutants.A limited number 116 of preclinical studies have detailed these EGFR TKIs.We sought to use commercially available

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Molas Baju Wara: Hybridity in Manggarai Rap Music

Rap music which has been popular since 2007 in Manggarai Dishwasher Door Panel region, East Nusa Tenggara, Indonesia, gave rise to rap hybrid phenomenon.The mixture between American rap music formats and local elements of Manggarai attracted the attention of young people in the region.One of the local songs that feature hybridity in rap Manggarai i

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Towards effective and efficient COVID-19 vaccination in Nigeria

Vaccines are prospective subverts in battling the COVID-19 virus ravaging the globe and the Nigerian cold-chain system needs a thorough overhaul in order to optimize vaccine distribution.This paper presents a situational analysis of the Nigerian cold chain system, the challenges and opportunities that exist.The problems plaguing the aforementioned

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